Don't forget to disable any screen savers, as they will make it keep starting again, Clive. My guess, however, regarding the general slowness of the system, would be that there is still something running in the background, which none of your spyware utilities have removed. Have you had a look under the Processes tab in Ctrl/Alt/Del, to see if anything is hogging resources? Have a try with
Ewido, which seems to find things some of the others don't. For the defrag, you could also try
EndItAll2, which will kill all running programs, except anything essential to run Windows. This might make the defrag a bit faster.