Theres a good program called Lock Folder that will do what you want.
That will make any folder or drive invisible to anyone but yourself.
When you install it you assign a key or combination of keys, say F12 and letter D at the same time to open up the programs log in box.
Enter your own details and you can access the protected folders and drives.
No one will know that you have restricted any folders or drives as they dont even show in safe mode.
Some one may notice that theres some space not accounted for on a drive, if they add up the space of visible folders but thats the only way they would know anythings hidden.
The program doesnt even show up in the ADD/Remove part of the control panel