Deleting "DUPLICATE" files usually results in a format and a complete reinstall, unless you are either very very good at identifying duplicates or are very very very lucky. Don't delete a duplicate file unless the other file is exactly the same Size, Date, and Name as the other.
If you do delete any files, Michelle, make sure you either keep them in the recycle bin for a couple of weeks, or even better, leave them where they are and slightly rename them. For example, if you wanted to delete a duplicate of the file "crap.dll" rename it something like "crap.dll.delete" Then, if a program starts looking for crap.dll you can do a search, change its name back to its original and "bobs your uncle". If, after several months, everything is working, you can search for the files named *.delete and get rid of them.
Personally, unless you are absolutely desperate for HD space, I would leave well alone.